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NDI-034858

SKU: orb1687140

Description

NDI-034858 (TAK-279) is a potent, selective TYK2 pseudokinase (JH2) domain inhibitor with sub-nanomolar affinity. It is a research tool for investigating IL-12/IL-23 signaling pathways in autoimmune disease models, supporting both in vitro mechanistic studies and in vivo preclinical research.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number2272904-53-5
MW460.49
Purity100.00%
FormulaC23H24N8O3
SMILESCNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1OC
TargetTyrosine Kinases,IL Receptor,JAK
SolubilityDMSO:45 mg/mL (97.72 mM)

Bioactivity

In Vitro
NDI-034858 (compound I-908) (10 μM) demonstrates inhibitory activity against Tyk2 and JAK enzymes. It achieves this by targeting the Tyk2 JH1 domain and the JAK JH1 domain, resulting in inhibition rates of less than 50% for both enzymes.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ILReceptor, IL-23, IL Receptor, IL-12, NDI 03485, NDI 034858, NDI03485, NDI034858, NDI-034858, Tyk2 JH2, Tyrosine Kinases, TyrosineKinases, TAK 279, TAK279, TAK-279
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

NDI-034858 (orb1687140)

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Available Sizes

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1 mg
¥ 4,030.00
5 mg
¥ 10,790.00
10 mg
¥ 16,900.00
25 mg
¥ 24,830.00
50 mg
¥ 33,410.00
100 mg
¥ 44,590.00
DispatchUsually dispatched within 3-5 working days
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