NDNA4

NDNA4 (compound 17) is a permanently charged, cell-impermeable inhibitor selectively targeting Hsp90α (IC50: 0.34 µM). It shows minimal cytotoxicity and, unlike many Hsp90 inhibitors, does not induce a heat shock response or degrade client proteins, making it a valuable tool for studying extracellular Hsp90α roles in oncology and cell migration research.