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NDT 9513727

SKU: orb1703037

Description

NDT 9513727 is a potent, selective, and competitive C5aR1 inverse agonist. It is a valuable research tool for investigating the role of C5a signaling in inflammatory and immune disorders, applicable in both in vitro assays and in vivo disease models.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number439571-48-9
MW573.68
Purity99.21%
FormulaC36H35N3O4
SMILESCCCCn1c(CN(Cc2ccc3OCOc3c2)Cc2ccc3OCOc3c2)c(nc1-c1ccccc1)-c1ccccc1
TargetComplement System
SolubilityEthanol:30 mg/mL (52.29 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.75 mM);DMSO:80 mg/mL (139.45 mM)

Bioactivity

Target IC50
C5aR (human):11.6 nM
In Vivo
NDT 9513727 (3-30 mg/kg) effectively inhibited C5a-induced neutropenia in vivo in both gerbils and cynomolgus macaques.
In Vitro
NDT 9513727 inhibited C5a-stimulated responses, including guanosine 5′-3-O-(thio)triphosphate binding, Ca2+ mobilization, oxidative burst, degranulation, cell surface CD11b expression and chemotaxis in various cell types with IC50s from 1.1 to 9.2 nM, respectively.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ComplementSystem, Complement System, complement 5a receptor (C5aR), NDT 9513727, NDT9513727, NDT-9513727
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

NDT 9513727 (orb1703037)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,040.00
5 mg
¥ 1,690.00
10 mg
¥ 2,340.00
25 mg
¥ 4,420.00
50 mg
¥ 7,020.00
100 mg
¥ 10,920.00
DispatchUsually dispatched within 5-10 working days
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