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Neuroprotective agent 11

SKU: orb3135636

Description

Neuroprotective agent 11 (Compound 1a) is an orally active polyphenolic compound that offers significant protection against cerebral ischemia. Its primary activities include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarct size, and improving behavioral symptoms in mice with cerebral ischemia. The mechanism involves downregulating inflammatory factors (iNOS, COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 is applicable for research in ischemia-related brain diseases, such as ischemic stroke.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Protein Biochemistry

Images & Validation

Key Properties

CAS Number3081915-81-0
MW606.57
FormulaC32H30O12
SMILESO[C@H]1[C@@H](C=2C(O[C@@H]1C3=CC(O)=C(O)C=C3)=C(CC)C(O)=CC2O)C4=C5C(C[C@H](O)[C@H](O5)C6=CC(O)=C(O)C=C6)=C(O)C=C4O
TargetNO Synthase,MDM-2/p53,Caspase,COX

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information