Nicardipine HCl

SKU: orb1309370

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Description

Nicardipine hydrochloride is a synthetic calcium channel blocker of the nifedipine family that inhibits vascular smooth muscle contraction, acting as a potent cerebral and coronary vasodilator. It is widely used in research to study hypertension, cerebral ischemia, and vascular pharmacology in both in vitro and in vivo experimental models.

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number	54527-84-3
MW	479.54 ∙ 36.46
Purity	>98%
Formula	C₂₆H₂₉N₃O₆ ∙ HCl
SMILES	C1(=C(C(C(=C(N1)C)C(=O)OC)c1cc(ccc1)[N+](=O)[O-])C(=O)OCCN(C)Cc1ccccc1)C.Cl
Target	Ion channel
Solubility	Soluble in Ethanol (up to 20 mg/ml) or in Water (up to 5 mg/ml).

Bioactivity

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Target IC50

Ca2+ channel (Cardiac):1 μM (IC50)

In Vitro

Nicardipine significantly reduced systolic blood pressure in spontaneously hypertensive rats. In spontaneously hypertensive rats, Nicardipine significantly decreased the intima-media thickness and increased the lumen area at the level of cerebral arteries and small molluscum arteriosum.Nicardipine increased the number of neurons in the occipital cortex and frontal cortex in the SHR and inhibited the proliferation and hypertrophy of GFAP-positive astrocytes.Nicardipine also increased the number of neurons in the CA1 area of the hippocampus. increase in the number of neurons in the CA1 region of the hippocampus and reduced the size and number of astrocytes in gray and white matter. Nicardipine (5 mg/kg) in combination with flunarizine (80 mg/kg) and nimodipine (80 mg/kg) significantly potentiated the protective effect of ethosuximide (50 mg/kg) or valproic acid (100 mg/kg) against clonic seizures in mice. Nicardipine (40 mg/kg, 2 times/day for 8 weeks) reduced plaque area by 49.2% in rabbits (cholesterol-fed).Nicardipine (40 mg/kg) reduced aortic cholesterol accumulation in cholesterol-fed rabbits by 74.5%.Nicardipine (100 mg/kg) caused a significant transient reduction in cat Nicardipine (100 mg/kg) caused a significant transient reduction in retinal blood flow in cats. Although Nicardipine (100 mg/kg) decreased mean arterial blood pressure in cats, it significantly increased blood flow to the ONH, suggesting that Nicardipine benefits optic nerve hypoplasia tissue.

Storage & Handling

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Storage	RT
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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mAChR, Nicardipine, Nicardipine HCl, Nicardipine hydrochloride, Nicardipine Hydrochloride, inhibit, Inhibitor, CalciumChannel, Adrenergic Receptor, AdrenergicReceptor, angina, Autophagy, blocker, blood, Ca channels, Ca2+ channels, Calcium Channel, cardiac, pressure, YC 93, YC 93 Hydrochloride, YC93, YC-93, YC93 Hydrochloride, YC-93 Hydrochloride, RS 69216, RS69216, RS-69216

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Compound Identifiers

PubChem CID

41114 ↗

Key Properties

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No computed properties available.

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Nicardipine HCl

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

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Nicardipine HCl (orb1309370)

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