Nicotinamide riboside

SKU: orb1308786

Description

This small molecule research compound elevates cellular NAD+ levels, thereby activating sirtuins SIRT1 and SIRT3. It is widely used in metabolic research to study oxidative metabolism and has demonstrated protective effects against diet-induced metabolic dysfunction in both in vitro and in vivo models.

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1341-23-7
MW	255.25
Purity	99.89% (May vary between batches)
Formula	C₁₁H₁₅N₂O₅
SMILES	O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)[N+]=2C=C(C(N)=O)C=CC2
Target	Endogenous Metabolite,Sirtuin
Solubility	H2O:50 mg/mL (195.89 mM);DMSO:125 mg/mL (489.72 mM)

Bioactivity

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In Vivo	The natural vitamin Nicotinamide riboside (NR) could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function.
In Vitro	Nicotinamide riboside (NR) supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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abnormalities, Alzheimer's, dietary, COVID-19, Endogenous Metabolite, Inhibitor, inhibit, orally, Nicotinamide riboside, niacin, oxidative, NAD+, PARP, metabolic, metabolism, vitamin, supplements, SIRT3, SIRT1, Sirtuin

Quality Guarantee

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Compound Identifiers

PubChem CID

439924 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Applications:	WB
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	FC, WB
Reactivity:	Human, Mouse
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IHC-P, WB
Predicted Reactivity:	Mouse
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, IHC, WB
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IHC, WB
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Nicotinamide riboside

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Compound Identifiers

Key Properties

Protocol Information

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