Nifuroxazide

SKU: orb1308168

Description

Nifuroxazide is a cell-permeable, nitrofuran antidiarrheal agent that acts as an inhibitor of STAT1, STAT3, and STAT5 transcription factor signaling. It is used in research to study STAT pathway biology in both cellular and animal models of inflammation, cancer, and autoimmune diseases.

Research Area

Infectious Disease & Virology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

−

Key Properties

−

CAS Number	965-52-6
MW	275.22
Purity	99.87%
Formula	C₁₂H₉N₃O₅
SMILES	OC1=CC=C(C=C1)C(=O)N\N=C\C1=CC=C(O1)[N+]([O-])=O
Target	STAT,Antibacterial,Antibiotic
Solubility	Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:18.33 mg/mL (66.6 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

−

In Vivo

Nifuroxazide does not affect the phosphorylation of Akt or MAPK. It inhibits the survival of myeloma cells by reducing the autophosphorylation of Jak kinases, thereby blocking the constitutive phosphorylation of STAT3, but has no effect on normal peripheral blood mononuclear cells. Nifuroxazide decreases the tyrosine phosphorylation of TYK2 and Jak, demonstrating selectivity towards TYK2 and Jak2 without impacting the tyrosine kinases of the EGF receptor or Src kinase. This effect is achieved through the reduction of Jak kinases' autophosphorylation, leading to the inhibition of constitutive phosphorylation of STAT3 in MM (multiple myeloma) cells and the downregulation of the STAT3 target gene, Mcl-1. Consequently, Nifuroxazide reduces the viability of primary myeloma cells and cell lines with activated STAT3 but does not affect normal peripheral blood mononuclear cells. It also blocks the survival signals provided by bone marrow stromal cells to myeloma cells. Compared to interactions with other cellular pathways, Nifuroxazide shows increased cytotoxicity when combined with the histone deacetylase inhibitor Trichostatin or the MEK inhibitor UO126, targeting STAT3.

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Antibiotic, Bacterial, Dicoferin, Diarlidan, inhibit, Nifuroxazid, Nifuroxazide, Inhibitor, STAT5, STAT1, STAT, STAT3

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

5337997 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Nifuroxazide (orb1308168)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

CAS Number:	1188487-83-3
MW:	279.24
Formula:	C₁₂H₅D₄N₃O₅

Purity:	>98%(HPLC)
CAS Number:	965-52-6
MW:	275.2
Formula:	C₁₂H₉N₃O₅

Nifuroxazide

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Nifuroxazide-d4 [orb1738187]

Nifuroxazide (Standard) [orb3025274]

Nifuroxazide [orb1223506]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Nifuroxazide (orb1308168)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors