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Nifurpirinol

SKU: orb1983235

Description

Nifurpirinol is an antimicrobial agent with acute toxicity in milkfish (Chanos chanos). It is used in research to selectively inhibit collagen production, as demonstrated in zebrafish models like the Fli//colRN line, making it a tool for studying tissue development and antimicrobial mechanisms in vivo.

Research Area

Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number13411-16-0
MW246.22
Purity99.70% (May vary between batches)
FormulaC12H10N2O4
SMILESO=[N+]([O-])C1=CC=C(/C=C/C2=CC=CC(CO)=N2)O1
TargetAntibacterial,Topoisomerase,Antibiotic
SolubilityDMSO:10 mg/mL (40.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.06 mM)

Bioactivity

In Vivo
Strong hyperglycemia was detected in fish treated with Nifurpirinol (523 ±113 mg/dl, n=8) as compared to control fish (65 ±13 mg/dl, n=9). This indicates that NFP is able to induce pancreatic beta cell ablation and thus acts as a substrate for NTR-mediated cell ablation.
In Vitro
Nifurpirinol-treated larvae show more cell debris and large CFP+ cells with a large cytoplasm and irregular nucleus which are presumably phagocytic cells having engulfed apoptotic CFP neurons. Furthermore, Nifurpirinol-treated larvae display much fewer cells with a normal morphology as compared to MTZ treated larvae, underpinning a more efficient ablation with Nifurpirinol.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Antibiotic, Bacterial, P7138, P-7138, P 7138

Similar Products

  • Nifurpirinol [orb2900539]

    >98% (HPLC)

    13411-16-0

    246.22

    C12H10N2O4

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 g, 2 mg
Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 100.00
5 mg
$ 170.00
10 mg
$ 240.00
25 mg
$ 430.00
50 mg
$ 610.00
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