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NLX-204 hydrochloride(2170405-10-2 free base)

SKU: orb1305961

Description

NLX-204 hydrochloride is a potent and selective serotonin 5-HT1A receptor agonist with a preference for ERK1/2 phosphorylation (pKi = 10.19). It is a valuable research tool for investigating neuropsychiatric disorders, with applications in both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

MW446.32
Purity99.59% (May vary between batches)
FormulaC20H23Cl2F2N3O2
SMILESO=C(N1CCC(CNCCOC2=NC=CC=C2)(CC1)F)C3=CC=C(C(Cl)=C3)F.Cl
Target5-HT Receptor
SolubilityDMSO:11 mg/mL (24.65 mM)

Bioactivity

In Vivo
NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein. Preliminary in vivo studies confirmed its promising pharmacokinetic profile. NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

5HTReceptor, 5HT Receptor, 2170405-10-2, 2170405-10-2 free base, 5-HT1A, NLX204 Hydrochloride, NLX-204 Hydrochloride, NLX204 hydrochloride(2170405102 free base), NLX 204 Hydrochloride, NLX 204 hydrochloride(2170405 10 2 free base)

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 160.00
1 ml x 10 mM (in DMSO)
$ 170.00
10 mg
$ 200.00
25 mg
$ 330.00
50 mg
$ 440.00
100 mg
$ 630.00
DispatchUsually dispatched within 3-5 working days
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