NMDA

SKU: orb1300618

Description

N-Methyl-D-aspartic acid (NMDA) is the selective D-isomer agonist for the NMDA receptor subtype of glutamate receptors. It is widely used in neuroscience research to study synaptic plasticity, excitotoxicity, and neuronal signaling in both cellular assays and animal models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	6384-92-5
MW	147.13
Purity	99.21% (May vary between batches)
Formula	C₅H₉NO₄
SMILES	CN[C@H](CC(O)=O)C(O)=O
Target	iGluR,Endogenous Metabolite,NMDAR
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.8 mM);H2O:30 mg/mL (203.9 mM);DMSO:10 mg/mL (67.97 mM)

Bioactivity

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In Vivo

Microinjection of NMDA (0.2 nM) significantly impacts male sexual behaviors, notably reducing both mount and intromission frequencies, while also shortening the latencies to intromission and ejaculation. Furthermore, NMDA markedly enhances, whereas AP-5 distinctly inhibits, ejaculatory behavior when observed during a 30-minute copulation test. When NMDA is bilaterally microinjected into the paraventricular nucleus (PVN), there is a notable increase in baseline lumbar sympathetic nerve activity (LSNA), with the peak increment of LSNA manifesting within 5 minutes of the procedure.

In Vitro

NMDA is an excitatory amino acid neurotransmitter, which only binds to the NMDA receptor without effecting other glutamate receptors (such as those for AMPA and kainate). NMDA specifically binds to the NR2 subunits of NMDA receptor, and then stimulates the open of non-specific cation channel which can allow the passage of Ca2+ and Na+ into the cell and K+ out of the cell. Activation of the NMDA receptor is able to produce the excitatory postsynaptic potential (EPSP), and trigger the increase of intracellular Ca2+ content which may further take participating in various signaling pathways. NMDA receptor plays a key role in a wide range of physiological (e.g. long-term potentiation and neuronal plasticity) and pathological processes (e.g. excitotoxicity and epilepsy).

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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N-Methyl-D-aspartic acid, NMDA, NMDA receptor, Ionotropic glutamate receptors, inhibit, iGluR, Inhibitor, EndogenousMetabolite, Endogenous Metabolite

Quality Guarantee

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Compound Identifiers

PubChem CID

22880 ↗

Key Properties

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No computed properties available.

Protocol Information

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Applications:	FC, IF, IHC-Fr, IHC-P
Predicted Reactivity:	Canine
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IF, IHC-Fr, IHC-P, WB
Predicted Reactivity:	Rat
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Recombinant
Conjugation:	Unconjugated

Applications:	ELISA, FC, IF, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, FC, ICC, IF, IHC, WB
Reactivity:	Human, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, FC, ICC, IF, IHC, WB
Reactivity:	Human, Mouse, Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

NMDA

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Key Properties

Protocol Information

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