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NMS-P937

SKU: orb1222915

Description

Onvansertib, also know as NMS-P937, PCM-075 and NMS1286937, is a n orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.

Research Area

Neuroscience

Images & Validation

Key Properties

CAS Number1034616-18-6
MW532.52
Purity>98% (HPLC)
FormulaC24H27F3N8O3
SMILESCN1CCN(CC1)c1cc(c(cc1)OC(F)(F)F)Nc1ncc2CCc3c(c2n1)n(nc3C(=O)N)CCO
TargetPLK1| PLK2| PLK3
SolubilityDMSO : 21 mg/mL. 39.44 mM;

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PCM-075 | PCM 075 | NMS1286937

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Protocol Information

NMS-P937 (orb1222915)

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Available Sizes

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500 mg
2 mg
¥ 1,040.00
5 mg
¥ 1,430.00
10 mg
¥ 1,950.00
25 mg
¥ 2,990.00
50 mg
¥ 4,420.00
100 mg
¥ 7,020.00
200 mg
¥ 8,840.00