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Nomilin

SKU: orb1222891

Description

Nomilin is an inducer of phase II detoxifying enzymes, showing anti-proliferative active on cultured human breast cancer cells.(In Vitro):Nomilin treatment significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown.(In Vivo):Nomilin attenuated blood-brain barrier (BBB) disruption in MCAO rats, which might be associated with alleviating the loss of tight junction proteins, including ZO-1 and occludin-5.

Images & Validation

Key Properties

CAS Number1063-77-0
MW514.57
Purity>98% (HPLC)
FormulaC28H34O9
SMILESCC(=O)OC5CC(=O)O[C@@](C)(C)[C@@H]6CC(=O)[C@]3(C)[C@H](CC[C@@]2(C)[C@@H](OC(=O)[C@H]1O[C@]123)c4ccoc4)[C@@]56C
TargetLTR
SolubilityIn Vitro: DMSO : 100 mg/mL (194.34 mM)

Bioactivity

In Vivo
Nomilin attenuated blood-brain barrier (BBB) disruption in MCAO rats, which might be associated with alleviating the loss of tight junction proteins, including ZO-1 and occludin-5.
In Vitro
Nomilin treatment significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Nomilin

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Protocol Information

Nomilin (orb1222891)

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Available Sizes

Select a size below

5 mg
¥ 1,040.00
10 mg
¥ 1,430.00
25 mg
¥ 2,600.00
50 mg
¥ 3,510.00
100 mg
¥ 5,070.00
500 mg
¥ 11,830.00