Notch Signaling Pathway

The Notch signaling pathway is a conserved cell signaling system present in most animals. Notch signaling is a critical pathway in cell-cell communication that controls cell fate decision, proliferation, differentiation, and apoptosis during development and in adult tissues.

The Notch signaling pathway begins with the interaction between Notch receptors (Notch1-4 in mammals) on one cell membrane and membrane-bound ligands (Jagged1/2 and DLL1/3/4) on the membrane of another cell. This binding causes a cascade of proteolytic cleavage events in the Notch receptor. Finally, the gamma secretase complex cleaves the Notch receptor to release the Notch Intracellular Domain (NICD).

The NICD then translocates to the nucleus to bind to the DNA-binding protein CSL (RBP-J kappa) and the co-activator Mastermind-like (MAML). This complex activates the transcription of Notch target genes, including members of the Hes and Hey gene families. Notch signaling pathway dysregulation causes a variety of diseases, including different cancers and developmental diseases such as T-cell acute lymphoblastic leukemia.

Our highly validated antibodies cover the full spectrum of Notch signaling, from receptors and ligands to downstream target genes.