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NS3694

SKU: orb1306090

Description

NS3694 is a small molecule apoptosis inhibitor that functions by blocking apoptosome assembly and subsequent caspase activation. This compound is utilized in research to study programmed cell death mechanisms in both cellular and animal models of diseases where apoptosis is dysregulated.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number426834-38-0
MW358.7
Purity99.92% (May vary between batches)
FormulaC15H10ClF3N2O3
SMILESOC(=O)c1ccc(Cl)cc1NC(=O)Nc1cccc(c1)C(F)(F)F
TargetApoptosis
SolubilityDMSO:250 mg/mL (696.96 mM)

Bioactivity

In Vitro
NS3694 (10, 50, and 100 μM) specifically inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. In MCF-casp3 cells, NS3694 (10-100 μM) inhibits dose-dependently caspase 9, 3, and 7 processing, DFF45/ICAD, and PARP cleavage, and DEVDase activity and inhibits TNF-induced effector caspase activation and apoptosis.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cytochrome c, Apaf-1, Apoptosis, apoptosome inhibitor, caspase-9, Inhibitor, inhibit, NS3694, NS-3694, NS 3694
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Key Properties

No computed properties available.

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Protocol Information

NS3694 (orb1306090)

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Available Sizes

Select a size below

1 mg
¥ 1,040.00
2 mg
¥ 1,170.00
1 ml x 10 mM (in DMSO)
¥ 1,560.00
5 mg
¥ 1,560.00
10 mg
¥ 2,080.00
25 mg
¥ 3,640.00
50 mg
¥ 5,070.00
100 mg
¥ 7,540.00
500 mg
¥ 15,470.00
DispatchUsually dispatched within 3-5 working days
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