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NSC145366

SKU: orb1737953

Description

NSC145366 is a C-terminal Hsp90 inhibitor that acts allosterically, promoting Hsp90 oligomerization and inhibiting N-terminal ATPase activity without competing for nucleotide binding. This selective client downregulation makes it a valuable research tool for studying Hsp90 function and client protein degradation in cancer biology and neurodegenerative disease models.

Images & Validation

Key Properties

CAS Number1052515-37-3
MW635.36
FormulaC37H63ClN2O4
SMILESC(C)(C)(C1=CC=C(OCC(CNC(CC(C)(C)C)(C)C)O)C=C1)C2=CC=C(OCC(CNC(CC(C)(C)C)(C)C)O)C=C2.Cl
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information