NSI-189 Phosphate

SKU: orb1306428

Description

NSI-189 Phosphate

Research Area

Signal Transduction

Images & Validation

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Item 1 of 1

Key Properties

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CAS Number	1270138-41-4
MW	464.5
Purity	99.63%
Formula	C₂₂H₃₃N₄O₅P
SMILES	OP(O)(O)=O.CC(C)CCNc1ncccc1C(=O)N1CCN(Cc2ccccc2)CC1
Target	Trk receptor,Others
Solubility	DMSO:65 mg/mL (139.94 mM)

Bioactivity

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In Vivo

NSI-189 actively stimulated remodeling of the stroke brain. Parallel in vitro studies further probed this remodeling process and demonstrated that oxygen glucose deprivation and reperfusion (OGD/R) initiated typical cell death processes, which were reversed by NSI-189 treatment characterized by significant attenuation of OGD/R-mediated hippocampal cell death and increased Ki67 and MAP2 expression, coupled with upregulation of neurogenic factors such as BDNF and SCF. These findings support the use of oral NSI-189 as a therapeutic agent well beyond the initial 6-hr time window to accelerate and enhance the overall functional improvement in the initial 6 months post stroke.

Storage & Handling

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Storage	keep away from moisture,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NSI 189 Phosphate, NSI189 Phosphate, NSI-189 Phosphate

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Compound Identifiers

PubChem CID

50922680 ↗

Key Properties

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No computed properties available.

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