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Nsp12-IN-2

SKU: orb3135975

Description

Nsp12-IN-2 (Compound 8), a triphosphate metabolite of 4'-thiouridine, functions as an inhibitor of SARS-CoV-2 Nsp12. It effectively suppresses the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, halting RNA synthesis and blocking the RNA capping and NMP capping of Nsp9. Nsp12-IN-2 shows potential for research into infections caused by SARS-CoV-2, other coronaviruses, and additional RNA viruses.

Research Area

Infectious Disease & Virology, Metabolism Research

Images & Validation

Key Properties

CAS Number667882-55-5
MW566.15
FormulaC9H12N2Na3O14P3S
SMILESO[C@H]1[C@H](N2C(NC(C=C2)=O)=O)S[C@@H]([C@H]1O)COP(OP(OP([O-])(O)=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+]
TargetSARS-CoV,Virus Protease,Drug Metabolite

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information