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NV-5138

SKU: orb1309310

Description

NV-5138 is a leucine-mimetic, orally bioavailable small molecule that acts as a selective intracerebral mTORC1 agonist via Sestrin2 binding. It serves as a research tool for studying mTOR signaling in the context of depression, with applications in both in vitro and in vivo neurological research models.

Research Area

Signal Transduction

Images & Validation

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NV-5138

Key Properties

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CAS Number2095886-80-7
MW181.18
Purity98.00% (May vary between batches)
FormulaC7H13F2NO2
SMILESCC(C)(C[C@H](N)C(O)=O)C(F)F
TargetmTOR
SolubilityDMSO:10.7 mg/mL (59.06 mM)

Bioactivity

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In Vivo
METHODS: Rats were orally administered NV-5138 (40, 80 or 160 mg/kg), and behavioral tests were started 24 hours later, including behavioral despair test (forced swimming test FST) and anxiety test (novelty suppression feeding test NSFT). In FST and NSFT, analyzes were performed 1 or 3 days after dosing. RESULTS NV-5138 significantly reduced immobility time and feeding latency, respectively, at 160 mg/kg but not at 40 or 80 mg/kg. METHODS: To test the duration of the antidepressant effect of NV-5138, rats were orally administered NV-5138 (160 mg/kg) and behavioral tests were started after 3 and 7 days or daily administration for 7 days (starting on day 0 ) of lower doses of NV-5138 (40 or 80 mg/kg, oral) RESULTS NV-5138 significantly reduced immobility time at both 3 and 7 days after FST administration; NV-5138 produced antidepressant effects at repeated low doses of NV-5138 (80mg/kg).

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Inhibitor, Mammalian target of Rapamycin, NV 5138, NV5138, NV-5138, mTORC1, mTOR, inhibit

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
129050791 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

Select a size below

1 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 220.00
5 mg
$ 270.00
10 mg
$ 410.00
25 mg
$ 820.00
50 mg
$ 1,270.00
100 mg
$ 1,820.00
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