NVP-2

SKU: orb1307939

Description

NVP-2 is a potent and selective ATP-competitive inhibitor of CDK9, inducing apoptosis with an IC50 of 0.514 nM. It also inhibits CDK1, CDK2, and CDK16 at micromolar concentrations. This probe is widely used in vitro to study transcription, cell cycle, and apoptosis mechanisms in cancer research.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	1263373-43-8
MW	513.07
Purity	99.76% (May vary between batches)
Formula	C₂₇H₃₇ClN₆O₂
SMILES	COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1
Target	CDK,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.8 mM);DMSO:100 mg/mL (194.91 mM)

Bioactivity

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Target IC50

CDK9:0.5 nM (IC50)

In Vitro

NVP-2 exhibits anti-proliferative activity against leukemia cells, specifically targeting KOPT-K1, Jurkat, P12-ICHIKAWA, DU.528, MOLT 16, HSB-2, PF-382, SKW-3, SUP-T11, DND-41, and HPB-ALL cells with IC50 values of 0.1688 μM, 0.1233 μM, 0.5736 μM, 0.1575 μM, 0.1620 μM, 0.1585 μM, 0.1808 μM, 0.2589 μM, 0.0918 μM, and 0.3023 μM, respectively. NVP-2 (0-10 nM; 72 hours) demonstrates CRBN-dependent anti-proliferative and pro-apoptotic effects in MOLT4 cells (IC50: 9 nM). At 250 nM for 24 hours, NVP-2 induces apoptosis in MOLT4 cells, increasing caspase-3 and γH2A.X expression, although this effect is significantly reduced upon compound washout. Additionally, NVP-2 (250 nM-1 μM; 6 hours) engages CDK9 in both wildtype and CRBN - / - MOLT4 cells without affecting CDK2 and CDK7.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CDK9, CDK, Cyclin dependent kinase, CRBN, Apoptosis, NVP 2, NVP2, NVP-2, Inhibitor, inhibit, Leukemia

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Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Sizes Available: 50 μl, 100 μl, 200 μl

NVP-2 [orb2985776]
Purity:
>98%
CAS Number:
1263373-43-8
MW:
513.1
Formula:
C₂₇H₃₇ClN₆O₂
Sizes Available: 25 mg, 5 mg
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Applications:
RNA-I
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Quality Guarantee

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Compound Identifiers

PubChem CID

66937006 ↗

Key Properties

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No computed properties available.

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Purity:	>98%
CAS Number:	1263373-43-8
MW:	513.1
Formula:	C₂₇H₃₇ClN₆O₂

NVP-2

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

HPCAL4 Rabbit Polyclonal Antibody [orb184104]

NVP-2 [orb2985776]

HPCAL4 siRNA (Mouse) [orb1837959]

HPCAL4 siRNA (Rat) [orb1832488]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

NVP-2 (orb1307939)

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