Oclacitinib maleate

SKU: orb1300351

Description

Oclacitinib maleate

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1640292-55-2
MW	453.51
Purity	99.92%
Formula	C₁₅H₂₃N₅O₂S·C₄H₄O₄
SMILES	OC(=O)\C=C\C(O)=O.CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Target	JAK,Tyrosine Kinases
Solubility	10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.28 mM);Ethanol:83 mg/mL (183.02 mM);H2O:15 mg/mL (33.08 mM);DMSO:83 mg/mL (183.02 mM)

Bioactivity

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Target IC50	JAK1-dependent:36 to 249 nM\|JAK:10 to 99 nM
In Vivo	Oclacitinib administered orally at a dose of 0.4–0.6 mg/kg twice daily is safe and efficacious in controllin the pruritus associated with allergic dermatitis. Oclacitinib provides itch relief within 24 h that persistes throug the treatment period, with over 70% o the treated dogs achieving a >50% reduction in pruritus by day. Read more...
In Vitro	Oclacitinib inhibits JAK family members by 50% at concentration ranging from 10 to 99 nM and does not inhibit a panel of 38 non-JAK kinases. Oclacitinib is most potent at inhibiting JAK1. Oclacitinib also inhibit the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. Oclacitinib has minimal effects on cytokines which does not activat the JAK1 enzyme in cell. Read more...

Storage & Handling

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Storage	keep away from direct sunlight,keep away from moisture,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Janus kinase, JAK, JAK1, JAK1-dependent, JAK2, JAK3, Oclacitinib, Oclacitinib maleate, Oclacitinib Maleate, Inhibitor, Tyrosine Kinases, TyrosineKinases, TYK2, PF 03394197, PF 03394197 Maleate, PF03394197, PF-03394197, PF03394197 Maleate, PF-03394197 maleate, PF-03394197 Maleate

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Compound Identifiers

PubChem CID

56843700 ↗

Key Properties

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No computed properties available.

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