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ODN 1668

SKU: orb1982511

Description

ODN 1668 is a Class B CpG oligodeoxynucleotide featuring a phosphorothioate backbone that acts as a potent TLR9 agonist. It stimulates IgM production and enhances antimicrobial immunity through CaTLR9-dependent signaling, making it a valuable tool for immunology research in both cellular assays and animal infection models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number1186063-66-0
MW6364.1
TargetTLR,Antibacterial
SolubilityH2O:20 mg/mL (3.14 mM)

Bioactivity

In Vivo
Treatment of male Wistar rats (175-200 g) with ODN 1668 (1, 5 mg/kg, intraperitoneal and subcutaneous) induced moderate fever and anorexia, and induced a significant increase in IL-6.
In Vitro
Treatment of mouse bone marrow-derived macrophages with ODN 1668 (6-60 µg/mL, 12-72 hours) increased the production of S100A8/A9, IL-6, and β-galactosidase. Treatment of anti-CD3-treated CD8+ T cells with ODN 1668 (0.3-3.0 μM, 4 days) promoted cell growth in a dose-dependent manner. Treatment of head kidney lymphocytes with ODN 1668 (0.25-32 μg/mL, 12 hours) promoted the proliferation of head kidney lymphocytes and enhanced the expression of immune genes.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ODN1668

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Protocol Information

Available Sizes

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1 mg
$ 170.00
5 mg
$ 310.00
10 mg
$ 460.00
25 mg
$ 730.00
50 mg
$ 1,000.00
100 mg
$ 1,320.00
200 mg
$ 1,770.00
DispatchUsually dispatched within 5-10 working days
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