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Ogerin

SKU: orb1307935

Description

Ogerin is a selective positive allosteric modulator of GPR68 (pEC50 6.83) that has been shown to inhibit fear memory recall in mouse models. It also exhibits inverse agonist/antagonist activity at the adenosine A2A receptor (Ki 220 nM) and weak antagonist activity at the serotonin 5-HT2B receptor (Ki 736 nM). This profile makes it a useful research tool for studying neuropsychiatric conditions and GPCR signaling in both in vivo and in vitro experiments.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1309198-71-7
MW307.35
Purity99.90% (May vary between batches)
FormulaC17H17N5O
SMILESNc1nc(NCc2ccccc2)nc(n1)-c1ccccc1CO
TargetGPCR,5-HT Receptor,Adenosine Receptor
SolubilityDMSO:250 mg/mL (813.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (16.27 mM)

Bioactivity

Target IC50
5-HT2B receptor:(ki)736 nM|GPR68:(pEC50)6.83 |A2A receptor:(ki)220 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, Ogerin, HEK293, GPR68, fibrotic diseases, G Protein-Coupled Receptor 68, fibroblasts, 5HTReceptor, 5HT Receptor, A2A, A2A receptoor, 5-HT2B receptor, 5-HT2B, AdenosineReceptor, Adenosine Receptor, TGF-β

Similar Products

  • Ogerin [orb1218944]

    >98% (HPLC)

    1309198-71-7

    307.35

    C17H17N5O

    2 mg, 10 mg, 25 mg, 200 mg, 50 mg, 100 mg, 1 g, 500 mg, 5 mg
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Key Properties

No computed properties available.

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Ogerin (orb1307935)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 910.00
5 mg
¥ 1,430.00
1 ml x 10 mM (in DMSO)
¥ 1,560.00
10 mg
¥ 2,080.00
25 mg
¥ 3,640.00
50 mg
¥ 5,850.00
100 mg
¥ 8,320.00
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