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Olutasidenib

SKU: orb1307932

Description

Olutasidenib

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1887014-12-1
MW354.79
Purity98.57% (May vary between batches)
FormulaC18H15ClN4O2
SMILESC[C@H](Nc1ccc(C#N)n(C)c1=O)c1cc2cc(Cl)ccc2[nH]c1=O
TargetIsocitrate Dehydrogenase (IDH),Dehydrogenase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.27 mM);DMSO:122 mg/mL (343.87 mM)

Bioactivity

Target IC50
IDH1 (R132C):114 nM (IC50)|IDH1 (R132H):21.2 nM (IC50)
In Vivo
In HCT116-IDH1-R132H/+ xenograft bearing female BALB/c Nude mice, Olutasidenib (three oral doses (12.5, 25, and 50 mg/kg) in 12-hour intervals) shows effective anti-tumor activity .
In Vitro
Olutasidenib is highly selective for IDH1 isoforms, showing no appreciable inhibition against wild-type IDH1 (> 20 μM) and IDH2 mutants (R172K and R140Q: both > 20 μM). Olutasidenib effectively suppresses 2-HG production by multiple IDH1-R132 mutants (R132H, R132C, R132G, R132L), displaying Olutasidenib (FT-2102) could be efficacious against most IDH1-R132 mutant-expressing tumors .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Olutasidenib, mutant, Isocitrate Dehydrogenase (IDH), Isocitrate Dehydrogenase, IsocitrateDehydrogenase, IsocitrateDehydrogenase(IDH), inhibit, FT 2102, FT2102, FT-2102, IDH, IDH1- R132C, IDH1- R132H, Inhibitor, 2-HG, R132C-IDH1, R132H-IDH1

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Olutasidenib (orb1307932)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,300.00
5 mg
¥ 2,860.00
1 ml x 10 mM (in DMSO)
¥ 2,990.00
10 mg
¥ 4,160.00
25 mg
¥ 7,280.00
50 mg
¥ 10,270.00
100 mg
¥ 14,170.00
200 mg
¥ 18,590.00
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