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ON123300

SKU: orb1300345

Description

ON123300 is a potent, multi-targeted kinase inhibitor with low nanomolar IC50 values against CDK4, Ark5, PDGFRβ, FGFR1, RET, and Fyn. It is a valuable research tool for studying cell cycle progression, oncogenic signaling, and tumor angiogenesis in both cellular and animal models of cancer.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1357470-29-1
MW429.52
Purity99.70%
FormulaC24H27N7O
SMILESCN1CCN(CC1)c1ccc(Nc2ncc3cc(C#N)c(=O)n(C4CCCC4)c3n2)cc1
TargetFGFR,Src,JAK,AMPK,c-RET,PDGFR,CDK
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
CDK4:3.9nM|FGFR1:26nM|Fyn:11 nM|PDGFRβ:26nM|Ark5:5nM|RET:9.2nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CDK, CDK6, CDK4, cRET, Cyclin dependent kinase, brain, AMPK, AMP-activated protein kinase, Ark5, ON 123300, ON123300, ON-123300, multi, inhibit, kinase, Inhibitor, FGFR1, glioma, Fyn, FYN, RET, RTK, Platelet-derived growth factor receptor, penetration, PDGFR, PDGFRβ, U87, tumor

Similar Products

  • ON123300 [orb1226455]

    >98% (HPLC)

    1357470-29-1

    429.5

    C24H27N7O

    25 mg, 50 mg, 5 mg, 100 mg, 10 mg, 500 mg, 1 g, 2 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

ON123300 (orb1300345)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
2 mg
¥ 1,300.00
5 mg
¥ 1,690.00
10 mg
¥ 2,470.00
25 mg
¥ 4,160.00
50 mg
¥ 6,500.00
100 mg
¥ 9,230.00
500 mg
¥ 18,330.00
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