Ontuxizumab Antibody

SKU: orb1944799

Description

Ontuxizumab (MORAb-004) is a humanized IgG1 monoclonal antibody targeting endothelin receptor B (TEM-1/CD248). It has demonstrated anti-tumor activity in preclinical models of melanoma and sarcoma, showing potential for therapeutic application in metastatic disease research.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	946415-62-9
MW	146.92 kDa
Purity	97.91% (SDS-PAGE); 99.85% (SEC-HPLC)
Target	EGFR,Others

Bioactivity

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In Vivo	In human CD248 knock-in mice, Ontuxizumab demonstrates antitumor effects when administered at a dose of 50 mg/kg via intravenous injection, given five times a day for five consecutive days. Read more...
In Vitro	Ontuxizumab induces internalization of CD248 in a dose-dependent manner, with a reduction of 46% in surface CD248 on human dermal fibroblasts after 12 hours of treatment with concentrations ranging from 0 to 100 μg/mL. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MORAb-004, Ontuxizumab

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Quick Database Links

Gene Symbol

EGFR,Others

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