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Org-12962

SKU: orb1706868

Description

Org-12962 is a potent and selective 5-HT2C receptor agonist (pEC50 7.01) with additional activity at 5-HT2A and 5-HT2B receptors. It demonstrates antiaversive effects in rat models of panic-like anxiety, supporting its research use in neuropsychiatric disorders and receptor pharmacology studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number132834-56-1
MW265.66
Purity98.38%
FormulaC10H11ClF3N3
SMILESFC(F)(F)C1=CC=C(N=C1Cl)N1CCNCC1
Target5-HT Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.82 mM);DMSO:225 mg/mL (846.95 mM)

Bioactivity

Target IC50
5-HT2B receptor:6.28 (pEC50)|5-HT2A receptor:6.38 (pEC50)|5-HT2C receptor:7.01 (pEC50)
In Vivo
Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%). Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) obviously enhances the postinjection frequency thresholds for self-interruption (F3.71=11.40) .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

5HTReceptor, 5-HT2C, 5-HT2C Receptor, 5-HT2A, 5-HT2B, 5-HT2B Receptor, 5-HT2A Receptor, 5HT Receptor, Org 12962, Org12962, Org-12962

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Org-12962 (orb1706868)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
10 mg
¥ 1,300.00
25 mg
¥ 1,690.00
50 mg
¥ 2,080.00
100 mg
¥ 2,730.00
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