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Org 27569

SKU: orb1305237

Description

Org 27569

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number868273-06-7
MW409.95
Purity98.00% (May vary between batches)
FormulaC24H28ClN3O
SMILESCCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc1ccc(cc1)N1CCCCC1
TargetCannabinoid Receptor
SolubilityDMSO:41 mg/mL (100.01 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.88 mM)

Bioactivity

In Vivo
ORG 27569 (3.2 and 5.6 mg/kg, intraperitoneally) significantly reduces both cue-induced and priming-induced reinstatement of cocaine and methamphetamine in rats. At a dosage of 30 mg/kg, intraperitoneally, ORG 27569 suppresses appetite independent of CB1 receptors and does not alter the discriminative stimulus effects of anandamide (AEA). Additionally, intracerebroventricular administration of ORG 27569 (100 μg) does not influence the pharmacological effects of systemic CP55,940 compared to a vehicle.
Cell Research
Cells expressing CB1 receptors are exposed to ORG27569 (10 μM) for 5 to 15 min. For toxin treatment to abrogate Gi coupling effects, PTX is added to the medium at 5 ng/ml. Following an 18-h incubation in the presence of toxin, cells are washed twice with PBS and treated with compounds. Cells are washed with ice-cold PBS, and cell lysates are obtained by harvesting the cells with ice-cold lysis buffer (150 mM NaCl, 1.0% IGEPAL CA-630, 0.5% sodium deoxycholate, 0.1% SDS, and 50 mM Tris, pH 7.5 containing 4-(2-aminoethyl)benzenesulfonyl fluoride, pepstatin A, E-64, bestatin, leupeptin, and aprotinin as protease inhibitors).(Only for Reference)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CB1, CB, Cannabinoid Receptor, CannabinoidReceptor, Inhibitor, Org27569, Org-27569, Org 27569, inhibit

Similar Products

  • Org 27569 [orb1223804]

    >98% (HPLC)

    868273-06-7

    409.95

    C24H28ClN3O

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
5 mg
$ 90.00
10 mg
$ 130.00
25 mg
$ 200.00
50 mg
$ 340.00
100 mg
$ 490.00
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