Oxotremorine M iodide

SKU: orb1708958

Description

Oxotremorine M iodide is a muscarinic acetylcholine receptor (mAChR) agonist that also enhances NMDA receptor activity. This dual function makes it a valuable research tool for studying cholinergic systems, synaptic plasticity, and neurodegenerative disease models in both in vitro and in vivo experiments.

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number	3854-04-4
MW	322.19
Purity	99.57%
Formula	C₁₁H₁₉IN₂O
SMILES	[I-].C[N+](C)(C)CC#CCN1CCCC1=O
Target	AChR
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.42 mM);DMSO:100 mg/mL (310.38 mM)

Bioactivity

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In Vivo	In male Sprague-Dawley albino rats, Oxotremorine M iodide (0.5 mg/kg; s.c.) increases DA release in the medial prefrontal cortex without affecting the nucleus accumbens. Read more...
In Vitro	Oxotremorine M iodide robustly elicits a phosphoinositide response (EC50 = 0.22 μM). Oxotremorine M iodide shows EC50s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively. Oxotremorine M iodide (0.1-30 μM) dose-dependently inhibits KCNQ2/3 currents. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Oxotremorine M Iodide, Oxotremorine methiodide, mAChR

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Compound Identifiers

PubChem CID

3027782 ↗

Key Properties

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No computed properties available.

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