Oxythiamine

SKU: orb1708948

Description

Oxythiamine is a thiamine antivitamin and transketolase inhibitor that suppresses cancer cell proliferation by blocking non-oxidative ribose synthesis. It induces cell cycle arrest and apoptosis, demonstrating potential anticancer activity in both in vitro and in vivo research models.

Research Area

Cell Biology, Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	136-16-3
MW	266.34
Purity	99.51% (May vary between batches)
Formula	C₁₂H₁₆N₃O₂S
SMILES	O=C1NC(=NC=C1C[N+]2=CSC(=C2C)CCO)C
Target	Endogenous Metabolite,Transketolase,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.51 mM);DMSO:40 mg/mL (150.18 mM)

Bioactivity

−

Target IC50	MIAPaCa2 cells:14.95 μM
In Vivo	s.c. injection C57BL/6 mice with LLC cells and supplemented the mice with a low- or a high-dose of Oxythiamine (250 or 500 mg/kg BW) daily for 5 wk. During the 5-wk period, Oxythiamine supplementation decreased plasma MMP-2 activity in a dose-dependent manner, and this effect was significant after 4 wk of tumor cell implantation. Read more...
In Vitro	Oxythiamine for MIA PaCa-2 cells 5-320 μM for 2 days IC50 is 14.95 μM MTT, MIA PaCa-2 cells concentrations of Oxythiamine (0 μM, 5 μM, 50 μM and 500 μM) for 48 hours two-dimensional gel electrophoresis (2DE). Oxythiamine altered protein expression in a dose dependent manner. The MIC and MFC values of Oxythiamine were in the range 0.08 × 103 to 10 × 103 mg/L. A549 cells were co-cultured with Oxythiamine (from 0.1 to 100 μM) for 6–12 h CCK-8 assay Oxythiamine contributes to a significant reduction of A549 cell viability of 11.7%, 23.6%, and 28.2% at 12, 24, and 48 h. Oxythiamine arrests the cell growth in G1 phase of cell cycle. Oxythiamine inhibits the growth of A549 cells by initially slowing-down cell cycle and by leading to apoptosis. Read more...

Storage & Handling

−

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Apoptosis, Hydroxythiamin, Thiamine, Oxythiamine, TK

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

8682 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Oxythiamine (orb1708948)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

CAS Number:	10497-04-8
MW:	425.29
Formula:	C₁₂H₁₇N₃O₈P₂S

CAS Number:	582-36-5
MW:	301.79
Formula:	C₁₂H₁₆ClN₃O₂S

CAS Number:	614-05-1
MW:	338.25
Formula:	C₁₂H₁₇Cl₂N₃O₂S

Oxythiamine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Oxythiamine diphosphate [orb1708947]

Oxythiamine chloride [orb2565599]

Oxythiamine diphosphate ammonium [orb1685761]

Oxythiamine chloride HCl [orb1737711]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Oxythiamine (orb1708948)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors