Ozagrel HCl

SKU: orb1300606

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Description

Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A2 synthase inhibitor. It is applied in research to study cerebral vasospasm and ischemia, with both in vitro enzymatic assays and in vivo models of post-operative stroke and related ischemic conditions.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	78712-43-3
MW	264.71
Purity	>98%
Formula	C₁₃H₁₂N₂O₂ HCl
SMILES	Cl.OC(=O)\C=C\c1ccc(Cn2ccnc2)cc1
Target	Thromboxane
Solubility	Soluble in Water (up to 25 mg/ml).

Bioactivity

−

Target IC50

TXA2 synthase:11 nM

In Vitro

Administration of 3 mg/kg Ozagrel significantly reduces the area and volume of cortical infarcts in rats following cerebral middle artery occlusion and reperfusion. Ozagrel also inhibits neural deficits in a rat model of microthrombosis and enhances deteriorated spontaneous motor activity and motor coordination in a conscious mouse model of cerebral ischemia-reperfusion. Furthermore, Ozagrel prevents the increase in lactate dehydrogenase activity in guinea pig pulmonary lavage fluid and blocks the production of thromboxane A(2) induced by oleic acid in guinea pigs, subsequently reducing the total protein concentration and the numbers of macrophages and neutrophils, as well as the expression of monocyte chemoattractant protein-1 and interleukin-8 mRNA in the entire lung. In cats, Ozagrel inhibits the reduction of brain tissue-specific gravity induced by reperfusion in the SHR model of cerebral ischemia-reperfusion and restores the decreased cortical PO(2) post-ischemia upon reperfusion. Ozagrel also increases the level of 6-keto-PGF(1alpha), a metabolite of prostacyclin I(2) (PGI(2)), in the brain tissue following ischemia-reperfusion.

Storage & Handling

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Storage	RT
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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OKY-046

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Compound Identifiers

PubChem CID

6438130 ↗

Key Properties

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No computed properties available.

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Ozagrel HCl (orb1300606)

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Purity:	>98% (HPLC)
CAS Number:	78712-43-3
MW:	264.71
Formula:	C₁₃H₁₂N₂O₂·HCl

Ozagrel HCl

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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