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P19As

SKU: orb3177261

Description

P19As is a BCR-ABL PROTAC degrader based on Asciminib, with a DC50 of approximately 200 nM for the wild-type BCR-ABL protein. It is capable of degrading the T315I mutant and demonstrates strong antiproliferative activity in BaF3-BCR-ABL (T315I) cells. P19As is applicable for research in chronic myeloid leukemia and acute lymphoblastic leukemia.

Images & Validation

Key Properties

CAS Number2635386-55-7
MW1017.45
FormulaC47H51ClF2N12O10
SMILESO=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCOCCN4C=C(CCCC(N[C@H]5CN(CC5)C6=C(C=C(C(NC7=CC=C(OC(Cl)(F)F)C=C7)=O)C=N6)C=8C=CNN8)=O)N=N4
TargetPROTACs,Bcr-Abl

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information