Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

P2L-003

SKU: orb3174354

Description

P2L-003 is a selective PAR2 antagonist with an IC50 of 0.62 μM in HT-29 cells. It blocks PAR2-mediated Ca2+ mobilization without affecting signaling through PAR1, PAR4, or ATP. P2L-003 dose-dependently inhibits downstream MAPK signaling cascades, including the phosphorylation of ERK1/2 and p38, and is applicable in colon cancer research.

Images & Validation

Key Properties

CAS Number1359416-20-8
MW472.99
FormulaC23H25ClN4O3S
SMILESO=C(N(C=1C=CC=CC1)CC2=NN(C3=C2CN(CC3)S(=O)(=O)CC=4C=CC=CC4Cl)C)C
Targetp38 MAPK,Protease-activated Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information