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p38 Kinase inhibitor 8

SKU: orb2944581

Description

p38 Kinase inhibitor 8 (Compound CCLXXVIII) is an orally bioavailable small molecule that potently inhibits p38β and JNK2α2 kinases with IC50 values of 6.3 nM and 53.6 nM, respectively. It has shown efficacy in reducing inflammation in a rat collagen-induced arthritis model, supporting its use in researching inflammatory and autoimmune disease pathways.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number815595-25-6
MW420.44
FormulaC22H21FN6O2
SMILESO=C(N1CCC(NC=2N=CC=C(N2)C3=C(N=C4OC=CN43)C5=CC=C(F)C=C5)CC1)C
Targetp38 MAPK,JNK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information