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p53 Activator 14

SKU: orb2945702

Description

p53 Activator 14 (Compound 7A), a neratinib derivative, is a cell-permeable small molecule that induces DNA damage, activates p53, and inhibits cancer cell proliferation (IC50=7.21 µM in HCT116). It demonstrates anti-metastatic, pro-apoptotic, and anti-angiogenic activity in both cellular assays and the chick CAM model, supporting its use in oncology research.

Research Area

Cancer Biology, Cell Biology

Images & Validation

Key Properties

CAS Number2922588-44-9
MW505.008
FormulaC28H29ClN4O3
SMILESO=C(NC1=CC=C(OCC2=NC=CC=C2)C(Cl)=C1)C3=CC=C(C=C3)CN4CCN(C(=O)C5CC5)CC4
TargetMDM-2/p53,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information