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palovarotene

SKU: orb1302775

Description

Palovarotene (Ro 3300074) is a selective RAR-γ nuclear receptor agonist. It is utilized in preclinical research to study pathways in bone development and heterotopic ossification, with applications in both in vitro assays and in vivo animal models.

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

CAS Number410528-02-8
MW414.54
Purity98.05%
FormulaC27H30N2O2
SMILESCC1(C)CCC(C)(C)c2cc(\C=C\c3ccc(cc3)C(O)=O)c(Cn3cccn3)cc12
TargetAutophagy,Retinoid Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.41 mM);DMSO:5.5 mg/mL (13.27 mM)

Bioactivity

In Vivo
Palovarotene effectively hinders post-traumatic chondrogenesis, osteogenesis, and significantly reduces trauma-induced ectopic bone formation. Through oral administration (1 mg/kg/day for 14 days, starting from either the first or fifth day post-operation), this compound markedly decreases subcutaneous and intramuscular heterotopic ossification (HO) in mice, achieving a reduction of 50 to 60% in HO, irrespective of treatment initiation timing or infection presence. In a specific study, Acvr1cR206H/+ mice were divided into two groups: one treated with Palovarotene and the other with a vehicle control for 14 days beginning on the injury's first day. Comparative analysis using micro-CT and 3D imaging on the 14th day revealed that while significant HO tissue masses developed in the vehicle-treated group, Palovarotene-treated mice showed over an 80% reduction in HO formation, based on bone volume/total volume metrics.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Autophagy, inhibit, palovarotene, Inhibitor, RARγ, RAR/RXR, R 667, R667, R-667, Retinoic acid receptors, Retinoid X receptors, Retinoid Receptor, RetinoidReceptor, Ro 3300074, Ro3300074, Ro-3300074

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    C27H30N2O2

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Key Properties

No computed properties available.

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palovarotene (orb1302775)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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2 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,300.00
5 mg
¥ 1,300.00
10 mg
¥ 1,820.00
25 mg
¥ 3,510.00
50 mg
¥ 5,330.00
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