Pam3CSK4 TFA (112208-00-1 free base)

SKU: orb1296767

Description

Pam3CSK4 TFA is a potent synthetic lipopeptide agonist of Toll-like receptors 1 and 2 (TLR1/2), with a reported EC50 of 0.47 ng/mL for human TLR1/2. It is widely used in immunology research to stimulate innate immune responses, both in vitro and in vivo, for studying inflammation, vaccine adjuvants, and macrophage activation.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	112208-01-2
MW	1852.33
Purity	99.01% (May vary between batches)
Formula	C₈₇H₁₅₉F₉N₁₀O₁₉S
SMILES	O=C(N[C@@H](CCCCN)C(=O)O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCCCCCCCCCCCCCC)CSCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O
Target	TLR
Solubility	H2O:16.67 mg/mL (9 mM)

Bioactivity

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Target IC50	TLR2:0.47 ng/mL (EC50)\|TLR1:0.47 ng/mL (EC50)
In Vivo	METHODS: Mice were intraperitoneally (ip) injected with Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) (5 mg/kg) from postnatal day (PND) 3 to 11. Pups were killed at PND12 or PND53, and brains, spleens, and livers were collected and weighed. Brain sections were stained for markers of brain injury. RESULTS Nine days after administration of Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA), mice showed a decrease in gray matter volume, white matter volume in the molecular layer of the forebrain and cerebellum, and an increase in spleen and liver weight at PND12. Read more...
In Vitro	Pretreatment with high doses of Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) (>25 μg/ml) improves the antimicrobial activity of neutrophils generated directly from mouse bone marrow. Read more...

Storage & Handling

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Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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112208-00-1, 112208-00-1 free base, Inhibitor, inhibit, Pam3CSK4, Pam3CSK4 TFA, Pam3CSK4 TFA (112208 00 1 free base), Pam3CSK4 TFA (112208001 free base), Pam-3CSK4 TFA (112208-00-1 free base), Pam3Cys-Ser-(Lys)4 TFA, TLR, TLR2/1, Toll-like Receptor (TLR)

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Compound Identifiers

PubChem CID

155977631 ↗

Key Properties

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No computed properties available.

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