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PBOX 6

SKU: orb1706844

Description

PBOX 6 is a pyrrolo-1,5-benzoxazepine compound exhibiting anticancer activity. It inhibits breast cancer cell proliferation in vitro and induces apoptosis in leukemia cells by JNK-mediated phosphorylation and inactivation of Bcl-2/Bcl-XL. Its research applications include studying apoptosis mechanisms and oncogenic signaling pathways in various cancer models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number290814-68-5
MW396.44
Purity98.71% (May vary between batches)
FormulaC25H20N2O3
SMILESCN(C)C(=O)OC1=C(Oc2ccccc2-n2cccc12)c1cccc2ccccc12
TargetMicrotubule Associated,Apoptosis
SolubilityDMSO:30 mg/mL (75.67 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.04 mM)

Bioactivity

In Vitro
PBOX 6, a potent apoptotic PBOX, does not elicit a general toxic effect in a rat R2C Leydig cell line. Treatment with PBOX 6 (0-25 μM, 16 h) induces dose- and time-dependent apoptosis and causes DNA fragmentation at 10 μM in HL-60 cells. Additionally, PBOX 6 (10 μM) induces apoptosis through the activation of caspase 3-like proteases in HL-60 cells. The apoptotic induction by PBOX 6 (10 μM) also leads to the accumulation of cytochrome c in the cytosol, independent of oxidative stress, peripheral-type benzodiazepine receptor (PBR), and NF-κB. In MCF-7 cells, PBOX 6 (25 μM) induces apoptosis through the activation of caspase-7. Furthermore, in K562 cells, PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol and nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner. This effect is also dependent on upstream activation of a trypsin-like serine protease, correlating with G2/M arrest.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, PBOX 6, PBOX6, PBOX-6
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Key Properties

No computed properties available.

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Protocol Information

PBOX 6 (orb1706844)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
¥ 1,300.00
5 mg
¥ 2,340.00
1 ml x 10 mM (in DMSO)
¥ 2,470.00
10 mg
¥ 3,120.00
25 mg
¥ 4,810.00
50 mg
¥ 6,890.00
100 mg
¥ 9,620.00
DispatchUsually dispatched within 3-5 working days
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