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PCO371

SKU: orb1307912

Description

PCO371 is a potent and selective small molecule agonist of the parathyroid hormone receptor 1 (PTH1R), demonstrating oral bioavailability. It serves as a research tool for studying bone metabolism and PTH signaling in both cellular assays and animal models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1613373-33-3
MW635.65
Purity99.25%
FormulaC29H32F3N5O6S
SMILESCc1cc(cc(C)c1CCS(=O)(=O)N1CCC2(CC1)N=C(NC2=O)c1ccc(OC(F)(F)F)cc1)N1C(=O)NC(=O)C1(C)C
TargetThyroid hormone receptor(THR)
SolubilityDMSO:120 mg/mL (188.78 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.87 mM)

Bioactivity

Target IC50
LLC-PK1 cells:4.1 mM (EC50)|PTHR1 (COS-7 cells):2.4 μM (EC50)|hPTHR1-delNT (COS-7 cells):17 μM (EC50)
In Vitro
In COS-7 cells expressing hPTHR1, PCO371 causes cAMP production (EC50: 2.4 μM). 2.5 μM in COS-7 cells transfected with hPTHR1-delNT, and also enhances the phospholipase C activity (EC50, 17 μM).

Storage & Handling

Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

THR, Thyroid hormone receptor, Thyroidhormonereceptor(THR), Thyroidhormonereceptor, thyroid hormone receptor-1 (PTHR1), Thyroid Hormone Receptor, Thyroid hormone receptor(THR), PTHR1, Inhibitor, inhibit, PCO 371, PCO371, PCO-371, 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

PCO371 (orb1307912)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,430.00
5 mg
¥ 2,470.00
1 ml x 10 mM (in DMSO)
¥ 3,120.00
10 mg
¥ 3,380.00
25 mg
¥ 5,720.00
50 mg
¥ 7,930.00
100 mg
¥ 10,920.00
DispatchUsually dispatched within 3-5 working days
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