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PD150606

SKU: orb1985180

Description

PD150606 is a selective, nonpeptide neuroprotective agent that functions as a calpain inhibitor, targeting both μ- and m-calpain isoforms. It has demonstrated efficacy in reducing calcium dysregulation and excitotoxic motor neuron death in vitro, showing potential for research in neurodegenerative disease models such as amyotrophic lateral sclerosis (ALS) and ischemic injury.

Research Area

Protein Biochemistry

Images & Validation

Key Properties

CAS Number179528-45-1
MW306.12
Purity98.19%
FormulaC9H7IO2S
SMILESOC(=O)C(\S)=C\c1ccc(I)cc1
TargetProteasome,Cysteine Protease
SolubilityDMSO:15 mg/mL (49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.53 mM)

Bioactivity

Target IC50
m-Calpain:0.37 μM (Ki)|μ-Calpain:0.21 μM (Ki)
In Vitro
PD 150606 (25 μM; 0-12 hours) can partially reduce apoptosis of neutrophils induced by staurosporine.

Storage & Handling

Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Compound T3525, Compound T-3525, Compound T 3525, CysteineProtease, Cysteine Protease, calpain
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

PD150606 (orb1985180)

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1 mg
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
DispatchUsually dispatched within 5-10 working days
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