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PD184161

SKU: orb1306264

Description

PD184161

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number212631-67-9
MW557.56
Purity99.40%
FormulaC17H13BrClF2IN2O2
SMILESFc1c(F)c(Nc2ccc(I)cc2Cl)c(cc1Br)C(=O)NOCC1CC1
TargetApoptosis,MEK
SolubilityDMSO:55 mg/mL (98.64 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (4.48 mM)

Bioactivity

Target IC50
MEK1/2:10-100 nM
In Vivo
In vivo, tumor xenograft P-ERK levels were significantly reduced 3 to 12 hours after an oral dose of PD184161 (P < .05). Contrarily, tumor xenograft P-ERK levels following long-term (24 days) daily dosing of PD184161 were refractory to this signaling effect. PD184161 significantly suppressed tumor engraftment and initial growth (P < .0001); however, established tumors were not significantly affected. In conclusion, PD184161 has antitumor effects in HCC in vivo that appear to correlate with suppression of MEK activity .
In Vitro
PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner more effectively than PD098059 or U0126. PD184161 inhibited cell proliferation and induced apoptosis at concentrations of > or = 1.0 microM in a time- and concentration-dependent manner.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

stroke, cancer, behavioral, Apoptosis, depressive, cell, Mitogen-activated protein kinase kinase, PD184161, PD-184161, PD 184161, neurons, inhibit, Inhibitor, HCC, MAPKK, MAP2K, MEK1/2, MEK
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Key Properties

No computed properties available.

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Protocol Information

PD184161 (orb1306264)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,040.00
2 mg
¥ 1,170.00
5 mg
¥ 1,560.00
10 mg
¥ 2,210.00
25 mg
¥ 4,290.00
50 mg
¥ 6,760.00
100 mg
¥ 9,490.00
200 mg
¥ 13,390.00
500 mg
¥ 19,760.00
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