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Peficitinib

SKU: orb1300333

Description

Peficitinib

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number944118-01-8
MW326.39
Purity99.84%
FormulaC18H22N4O2
SMILES[H][C@]12CC3C[C@]([H])(CC(O)(C3)C1)C2Nc1c(cnc2[nH]ccc12)C(N)=O
TargetJAK,Tyrosine Kinases
SolubilityH2O:<1 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.13 mM);Ethanol:<1 mg/mL;DMSO:60 mg/mL (183.83 mM)

Bioactivity

Target IC50
TYK2:4.8 nM|JAK2:5.0 nM|JAK1:3.9 nM|JAK3:0.7 nM
In Vivo
In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score.
In Vitro
ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5).

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

rheumatoid arthritis, splenocytes, Tyk2, TyrosineKinases, Tyrosine Kinases, ASP015K, inhibit, JAK3, Janus kinase, JAK2, JAK, JAK1, JNJ54781532, JNJ-54781532, JNJ 54781532, Peficitinib, lymphocytes, Inhibitor, IL-2

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Quality Guarantee

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Key Properties

No computed properties available.

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Peficitinib (orb1300333)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 1,040.00
5 mg
¥ 1,300.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
10 mg
¥ 1,950.00
25 mg
¥ 3,120.00
50 mg
¥ 4,420.00
100 mg
¥ 6,630.00
200 mg
¥ 9,360.00
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