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Pemetrexed disodium heptahydrate

SKU: orb3027182

Description

Pemetrexed disodium heptahydrate is a multi-target antifolate agent that potently inhibits thymidylate synthase, dihydrofolate reductase, and GARFT, disrupting nucleotide synthesis. Its application in research includes in vitro and in vivo studies for cancers such as non-small cell lung cancer and malignant pleural mesothelioma.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number357166-29-1
MW597.49
Purity99.78% (May vary between batches)
FormulaC20H33N5Na2O13
SMILESO.O.O.O.O.O.O.[Na+].[Na+].Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)NC(CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1
TargetDNA/RNA Synthesis,Antifolate,DHFR,Autophagy
SolubilityH2O:80 mg/mL (133.89 mM)

Bioactivity

Target IC50
GARFT:65 nM (Ki)|DHFR:7.2 nM (Ki)|TS:1.3 nM (Ki)
In Vivo
The survival analysis results showed that the survival time of mice treated with Pemetrexed disodium heptahydrate combined with Pemetrexed was significantly longer than that of mice treated with Pemetrexed disodium heptahydrate alone, rat IgG combined with Pemetrexed, or those receiving no treatment.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Protocol Information

Available Sizes

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25 mg
$ 80.00
50 mg
$ 90.00
100 mg
$ 110.00
500 mg
$ 210.00
DispatchUsually dispatched within 5-10 working days
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