Pergolide mesylate salt

PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat parkinson disease and hyperprolactinemiabut withdrawn from some markets due to potential for heart valve diseases.(In Vitro):Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process.(In Vivo):Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance .