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PF-06263276

SKU: orb1706817

Description

PF-06263276 is a potent and selective pan-JAK inhibitor, demonstrating IC50 values of 2.2 nM (JAK1), 23.1 nM (JAK2), 59.9 nM (JAK3), and 29.7 nM (TYK2). This small molecule is a valuable research tool for investigating JAK/STAT signaling in autoimmune and inflammatory disease models, both in cellular and preclinical studies.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1421502-62-6
MW566.63
FormulaC31H31FN8O2
SMILESCCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2CCN(Cc2[nH]1)C(=O)c1cnc(cn1)N1CCCCC1
TargetOthers,JAK,STAT

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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2 mg
$ 140.00
5 mg
$ 240.00
50 mg
$ 790.00
100 mg
$ 1,230.00
DispatchUsually dispatched within 5-10 working days
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