Cart summary

You have no items in your shopping cart.

PF-06869206

SKU: orb1296274

Description

PF-06869206

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2227425-05-8
MW374.75
Purity99.79%
FormulaC15H14ClF3N4O2
SMILESCc1[nH]c2c(N3CCO[C@H](CO)C3)c(C#N)c(nc2c1Cl)C(F)(F)F
TargetSodium-dependent phosphate transporter,Sodium Channel
SolubilityDMSO:120 mg/mL (320.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.67 mM)

Bioactivity

Target IC50
SLC34A1:380 nM
In Vivo
In rodent PK, PF-06869206 show moderate clearance In both rat and mouse. Oral bioavailability at 5 mg/kg is good in rat and moderate in mouse. At higher oral doses of 50 mg/kg, supraproportional increases in exposure are observed In both species, suggestive of saturation of clearance. PF-06869206 has moderate terminal elimination half-life (t1/ = .35 h, and 0.75 h for Wistar-Han rats (10 mg/kg, iv), and C57BL6 mice (1 mg/kg, iv)).
In Vitro
PF-06869206 (380 nM) shows NaPi2a Inhibition potency. PF-06869206 is profiled for potency in the rodent NaPi2a and NaPi2c cell lines. PF-06869206 shows comparable submicromolar activity fo the human, rat, and mouse NaPi2a isoforms IC50 : 0.4 μM/0.54 μM for rat/mouse NaPi2a).
Animal Research
Male Wistar-Han rats are treated with PF-06869206 (1 mg/kg, 5 mg/kg, and 50 mg/kg; 2 L/kg for iv or 10 L/kg for po). C57BL6 mice are treated with PF-06869206 (1 mg/kg, 5 mg/kg, and 50 mg/kg; 2 L/kg for iv or 10 L/kg for po).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, Na channels, Na+ channels, PF 06869206, PF06869206, PF-06869206, Sodium Channel, SodiumChannel, Sodiumdependent phosphate transporter, Sodiumdependentphosphatetransporter, SLC34A1

Similar Products

  • PF-06869206 [orb1218407]

    >98% (HPLC)

    2227425-05-8

    374.8

    C15H14ClF3N4O2

    5 mg, 10 mg, 2 mg, 1 g, 500 mg, 200 mg, 50 mg, 100 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

PF-06869206 (orb1296274)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

100 mg
1 ml x 10 mM (in DMSO)
¥ 910.00
5 mg
¥ 1,040.00
10 mg
¥ 1,300.00
25 mg
¥ 2,210.00
50 mg
¥ 3,510.00