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PF-4348235 2HCl

SKU: orb2695143

Description

PF-4348235 2HCl is a dual-acting small molecule bronchodilator, functioning as an adrenergic agonist and muscarinic antagonist. It is utilized in respiratory research, particularly for investigating therapeutic mechanisms in chronic obstructive pulmonary disease (COPD) models, both in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

MW790.24
Purity99.85% (May vary between batches)
FormulaC36H51Cl3N4O7S
SMILESCl.Cl.CS(=O)(=O)Nc1cc(ccc1O)[C@@H](O)CNCCCCCCCCCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccc(O)c(Cl)c1
TargetAdrenergic Receptor,AChR

Bioactivity

Target IC50
M3 mAChR (human):0.73 nM (Ki)|β2-adrenoceptor:3.7 nM (EC50)
In Vitro
PF-4348235 2HCl (Compound 15) has an EC50 value of 3.7 nM for β2-adrenergic receptors, and the Ki value of PF-4348235 2HCl for human M3 receptors is 0.73 nM.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PF-4348235 2HCl(1017857-38-3 Free base), PF43482352HCl(1017857383Freebase), PF4348235 2HCl, β2AR/M-receptor agonist-2 2HCl
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 300.00
5 mg
$ 630.00
10 mg
$ 840.00
25 mg
$ 1,210.00
50 mg
$ 1,630.00
DispatchUsually dispatched within 5-10 working days
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