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PF07104091

SKU: orb1297928

Description

PF07104091 is a selective CDK2 inhibitor that induces cell cycle arrest and apoptosis, thereby suppressing tumor cell proliferation. It is a valuable research tool for studying cell cycle dynamics and oncology, with applications in both in vitro and in vivo cancer models.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2460249-19-6
MW404.46
Purity99.59% (May vary between batches)
FormulaC19H28N6O4
SMILESN(C(=O)C1=CC(COC)=NN1C)C2=CC(=NN2)[C@@H]3C[C@H](OC(NC(C)C)=O)CC3
TargetCDK
SolubilityDMSO:55 mg/mL (135.98 mM)

Bioactivity

In Vitro
PF-07104091 hydrate (Example 13) inhibits CDK1/cyclin A2, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9, with Kis of 110, 238, 465 and 117 nM. METHODS: We explored whether CDK2 activity could be completely abolished by pharmacological treatment with supraphysiological doses of PF3600 (10 μM) or PF4091 (20 μM). RESULTS We observed an immediate collapse of the DHB reporter signal below the mitotic nadir, without a hump.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PF07104091, PF-07104091, PF 07104091, CDK2
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

PF07104091 (orb1297928)

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Available Sizes

Select a size below

1 mg
¥ 5,460.00
2 mg
¥ 7,670.00
5 mg
¥ 11,830.00
1 ml x 10 mM (in DMSO)
¥ 13,130.00
10 mg
¥ 17,030.00
25 mg
¥ 25,090.00
50 mg
¥ 33,670.00
100 mg
¥ 45,110.00
DispatchUsually dispatched within 3-5 working days
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