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Phenylephrine

SKU: orb1307589

Description

Phenylephrine is a selective α1-adrenergic receptor agonist, demonstrating highest affinity for the α1D subtype. It is widely used in research to study vascular tone and blood pressure regulation in both in vitro receptor binding assays and in vivo physiological models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number59-42-7
MW167.21
Purity99.89%
FormulaC9H13NO2
SMILESCNC[C@H](O)c1cccc(O)c1
TargetAdrenergic Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (29.9 mM);DMSO:100 mg/mL (598.05 mM);H2O:5 mg/mL (29.9 mM)

Bioactivity

Target IC50
α1D-adrenoceptor:5.86 (pKi)|α1A-adrenoceptor:4.70 (pKi)|α1B-adrenoceptor:4.87 (pKi)
In Vivo
Phenylephrine could enhance the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. Perfusion of hearts with Phenylephrine (100 μM) induces a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as Phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes .
In Vitro
Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates Phenylephrine-induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

L-Phenylephrine, (R)-(-)-Phenylephrine, Adrenergic Receptor, AdrenergicReceptor, α1A-adrenergic receptor, α1D-adrenergic receptor, α1B-adrenergic receptor

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Key Properties

No computed properties available.

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Phenylephrine (orb1307589)

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% DMSO +
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% Tween 80 +
%

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1 ml x 10 mM (in DMSO)
¥ 1,170.00
500 mg
¥ 1,170.00
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