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PhiKan 083

SKU: orb1307883

Description

PhiKan 083 is a small molecule carbazole-based compound utilized in research. It serves as a tool compound for investigating protein aggregation pathways, particularly in cellular and biochemical assays related to neurodegenerative disease models.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number880813-36-5
MW238.33
Purity98.20% (May vary between batches)
FormulaC16H18N2
SMILESCCn1c2ccccc2c2cc(CNC)ccc12
Targetp53|||Mdm2
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (16.78 mM);DMSO:115 mg/mL (482.52 mM);Ethanol:100 mg/mL (419.59 mM)

Bioactivity

Target IC50
p53-Y220C (Ln229 cells):150 μM(Kd) |p53-Y220C:167 μM(Kd)
In Vitro
PhiKan 083 reduces the cell viability of engineered variants of Ln229 cells, in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, MDM-2/p53, inhibit, p53/MDM2, PhiKan 083, PhiKan083, PhiKan-083

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 70.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 160.00
25 mg
$ 290.00
50 mg
$ 390.00
100 mg
$ 530.00
500 mg
$ 1,100.00
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