Phloretin

SKU: orb1221973

Description

Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot. It promotes potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells.

Images & Validation

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Key Properties

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CAS Number	60-82-2
MW	274.28
Purity	>98% (HPLC)
Formula	C₁₅H₁₄O₅
SMILES	c1(c(c(cc(c1)O)O)C(=O)CCc1ccc(cc1)O)O
Target	SGLT1\| SGLT2
Solubility	DMSO : 50 mg/mL 182.30 mM; H2O : < 0.1 mg/mL

Bioactivity

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In Vivo

Animal model: Collagen-Induced Arthritis (CIA) Mice. Dosage: 50 or 100 mg/kg. Administration: Oral adminstration. Result: Showed mitigation of clinical symptoms of RA in addition to reduced inflammation of hind-limbs compared to the control group.

In Vitro

Apoptosis Analysis Cell line: BEL-7402 cell. Concentration: 40-160 μM. Incubation time: 24 hours. Result: Induced cell apoptosis and activated caspase 3, 6 and 9. Western blot analysis. Cell line: 3T3-L1 adipocytes. Concentration: 0 μM, 3 μM, 10 μM, 30 μM, 100 μM. Incubation time: 24 hours. Result: Inhibited PPAR-γ, C/EBPα and C/EBPβ expression. Western blot analysis. Cell line: 3T3-L1 adipocytes. Concentration: 0 μM, 3 μM, 10 μM, 30 μM, 100 μM. Incubation time: 24 hours. Result: Upregulated the expression of p-ACC-1, p-AMPK, p-AMPKα and β.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NSC 407292 | RJC 02792

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Gene Symbol

SGLT1| SGLT2

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Phloretin (orb1221973)

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Purity:	98.53% (May vary between batches)
CAS Number:	60-82-2
MW:	274.27
Formula:	C₁₅H₁₄O₅

CAS Number:	2058292-99-0
MW:	612.584
Formula:	C₃₁H₃₂O₁₃

MW:	598.554
Formula:	C₂₇H₃₄O₁₅

CAS Number:	3850-43-9
MW:	223.23
Formula:	C₁₁H₁₃NO₄

Purity:	>98% (HPLC)
CAS Number:	446-71-9
MW:	302.28
Formula:	C₁₆H₁₄O₆

Phloretin

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Phloretin (orb1221973)

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